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Yale-New Haven Hospital, New Haven, Connecticut, USA HealthLINK: Women's Health

December 18, 2000

News this month
Regular vigorous exercise curbs risk of sudden death

A sedentary lifestyle is one of the primary risk factors for heart disease, and regular exercise has been promoted as a way to prevent heart disease as well as stroke. Yet, sudden bursts of vigorous exertion can be dangerous for the heart and may lead to sudden cardiac arrest, which kills about 225,000 Americans each year.

Men who exercised at least five times a week had a much lower risk of sudden death related to vigorous exertion.

To understand more about the connection between exercise and sudden cardiac arrest, researchers analyzed data from the Physicians’ Health Study, a study tracking 21,481 male physicians between the ages of 40 and 84 for 12 years. The subjects were free of heart disease at the beginning of the study. The researchers found men who exercised at least five times a week had a much lower risk of sudden death related to vigorous exertion, about seven times less, than those who only exercised once a week. In fact, compared to rest, the once-a-week exercisers had a 74-fold increase in sudden cardiac death during vigorous exertion. The frequent exercisers had an 11-fold increase.

Researchers compared the men’s risk of sudden death during and up to 30 minutes after an episode of vigorous exertion with that during periods of lighter or no exertion. They also evaluated whether habitual vigorous exercise modified the risk of sudden death associated with strenuous exertion.

The study, which appeared in the November 8 issue of the New England Journal of Medicine (NEJM), defined vigorous exercise as a range of activities from racquetball to heavy yard work. Lead author Christine Albert, MD, a cardiologist and researcher at Brigham and Women’s Hospital, and a team of researchers at three Boston hospitals and the Harvard and University of Miami public health schools found sudden cardiac arrest was the cause of death in 122 of the 21,481 subjects.

While sudden death was relatively uncommon in the group studied—one death per 1.5 million episodes of vigorous exercise—it still highlights the benefits of habitual vigorous exercise in reducing the risk of sudden death associated with exertion.

“Easing into exercise and continuing a regular program cuts risk.”
- Christine Albert, MD

Start slow, but be consistent
"The message is, if you are going to begin a vigorous exercise program, then build up to it gradually and also ask the advice of your physician before doing so" said Dr. Albert. "Easing into exercise and continuing a regular program cuts risk. Start out with moderate levels and gradually move to a tougher workout. Exercise isn’t necessarily just playing sports or working out at the gym; anything that’s really going to cause you to sweat is considered ‘vigorous exertion.’"

Those who are sedentary should not engage in physically challenging activity abruptly. An editorial that appeared in the same issue of the NEJM points out the relationship between exercise and heart disease is complex: "Their results substantiate the paradox of exercise—that vigorous physical exertion can be regarded as a two-edged sword; it can simultaneously increase the short-term risk of sudden death and also offer protection from this risk in those who regularly engage in exercise."

According to Dr. Albert, more research is needed to determine if the findings apply to women.



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Barry L. Zaret, M.D.

Exercise benefit outweighs the risk

Findings from the Physicians’ Health Study are consistent with much of the research that has focused on the benefits of exercise on our health and well-being, although it clearly underscores the risks of sudden exertion for those who are not well conditioned.

"Vigorous exercise can increase the short-term risk of sudden death, but it also offers protection from this risk for those who exercise regularly."

Although the Physicians’ Health Study was originally designed to look specifically at the benefits and risk of aspirin and beta carotene in the prevention of cardiovascular disease and cancer, many secondary studies have analyzed the huge repository of data. The findings of this study underscore both the benefit and the danger of vigorous exercise and make an important point for people who are interested in undertaking an exercise program. Vigorous exercise can increase the short-term risk of sudden death, but it also offers protection from this risk for those who exercise regularly.

This seeming paradox shouldn’t discourage anyone from considering an exercise program because the evidence of its benefits far outweighs its risks.

"Exercise should be approached from a very individualized perspective."

Look before you leap
Exercise should be approached from a very individualized perspective. It’s not one size fits all. There are cardiovascular and orthopedic issues that need to be considered before you lace up your running shoes.

Here’s what I suggest: It’s a good idea to see your physician before you embark on an exercise program if:

  • You’re over 40 and haven’t exercised before
  • You’ve been sedentary for many years
  • You have risk factors such as hypertension, hypercholesterolemia (high blood levels of cholesterol), a positive family history of premature cardiovascular disease, or if you have cardiac disease.

Your physician might think it makes sense for you to have a stress test, which I personally think is a reasonable strategy. A stress test is monitored exercise on a treadmill or stationary bicycle in a doctor’s office or hospital. It’s helpful in determining safe levels of exercise, especially if you have angina or other symptoms of coronary disease.

Developing an exercise plan
Once you have your physician’s approval, I recommend giving some consideration to putting together a formal graduated program. Keep a notebook and set goals for yourself. Start at a low level and gradually, over time, increase both the intensity and duration of your exercise, whether it’s walking, running, swimming or aerobics.

I emphasize to my patients who are starting to exercise seriously for the first time that this is the beginning of something they should do for the rest of their lives. It’s not something you’ll accomplish in a month or two months.

"Starting at a low exertion level is important for… your heart and. . .the safety of your joints and muscles."

Starting at a low exertion level is important for the health of your heart and also for the safety of your joints and muscles. There’s nothing more discouraging than finally making a commitment to leave sedentary life behind and then develop a hip problem or knee problem that makes it difficult for you to continue.

It’s also important to learn how to exercise the right way. Stretching is vitally important, but many people begin their sessions with stretching when their muscles are cold and prone to tearing. Start your activity at a low level, warm up gradually, complete your workout and then stretch. Some of my patients either do some reading about exercise or consult with a personal trainer to get them on the right road.

Weight work and cross training spread the stress
As we get older, it’s important not to just do aerobic exercise, which includes activities like running, bicycling and walking. You should also consider some low level weight work, which can help in several ways. It tones your body and makes you look and feel better, and it also increases your lean body tissue and reduces fat. The more muscle you have, the higher your metabolism and the more calories you burn, which makes it easier to keep your weight under control. And there’s more—weight work can help you build bone density—a particularly important benefit for women who may be at risk for osteoporosis.

Cross training is also one way for you to exercise frequently and avoid stress injuries. If you go to a gym, vary your cardiovascular workout by alternating sessions on the treadmill, bicycle and Nordic track. This routine will relieve the stress on any one group of muscles and joints and help you avoid injury.

Exercise for life
How often should you exercise? I recommend working out four days a week to my patients. Three days will be beneficial, but five days is probably optimal. And don’t forget to incorporate movement into your daily life. Skip the elevator and park farther away from the grocery store. It all adds up. Exercising becomes a way of life, and those who get the go-ahead from their physicians will find it helps weight control, relieves stress, increases energy, lowers blood pressure, improves your cholesterol profile and decreases your risk of developing heart disease.


Dr. Zaret is chief of cardiovascular medicine at Yale-New Haven Hospital, medical director of the Yale-New Haven Heart Center and professor and chair of cardiovascular medicine at the Yale University School of Medicine.


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