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March 15, 2002
News this month
Poll shows people with diabetes unaware of risk for heart disease
Even though heart disease and stroke are the leading killers of
people with diabetes, more than two-thirds of people suffering from
this disease are not aware of their heightened risk of developing
cardiovascular disease, according to a recent poll. The poll, which
was commissioned by the American Diabetes Association (ADA) and
American College of Cardiology (ACC), surveyed 2,008 individuals
between August and October 2001.
Heart disease and stroke are the leading
killers of people with diabetes.
More than 16 million Americans have diabetes and that figure
is growing at an alarming rate, said Health and Human Services
Secretary Tommy G. Thompson in announcing the survey. Sixty-five
percent of people with diabetes in the U.S. die from heart attacks
or strokes. Unfortunately, most of them are not aware of the link
between diabetes and heart disease and the things they can do to
reduce their risk.
Three-quarters of the patients with diabetes surveyed reported
having such risk factors for heart disease as high blood pressure,
high cholesterol, obesity and smoking, but they saw no connection
between these problems and their diabetes.
This research clearly illustrates the gap between perception
and reality, said Christopher D. Saudek, MD, ADA president.
The harsh reality is that if you have diabetes, you have a
two to four times greater likelihood of having a heart attack than
if you do not have diabetes.
Three-quarters of diabetic patients
surveyed reported having risk factors for heart disease
but
saw no connection between these problems and their diabetes.
Survey findings
The survey also found:
- 52 percent do not feel at risk for a heart
problem.
- 53 percent do not feel at risk for stroke.
- 60 percent do not feel at risk for high
blood pressure or high cholesterol.
- 16 percent of respondents could not
name one important thing they could do to reduce their risk of
heart attack or stroke.
These misconceptions may be partially related to physician practices.
Fifty-two percent of those surveyed, for example, said their physician
had never discussed lowering blood pressure and 45 percent received
no information about lowering cholesterol.
Many knew little about the steps
they can take to reduce their risks for heart disease.
Most of those surveyed knew more about disabilities associated
with their disease such as kidney damage, blindness and amputation
than they did about cardiovascular complications that are often
fatal. More disturbing, according to Dr. Saudek, is that many of
them knew little about the steps they can take to reduce their risks
for heart disease, including taking aspirin, quitting smoking and
lowering their cholesterol.
Incidence of diabetes growing
While heart disease is the No. 1 killer of all Americans, patients
with diabetes are at particular risk because high blood sugar damages
their blood vessels. The number of people with diabetes in the United
States has increased by nearly 50 percent in the past decade, with
the economic toll pegged at $100 billion annually and rising. The
Centers for Disease Control and Prevention project the current number
of patients with diabetes will grow by 165 percent over the next
50 years.
| Diabetes and Heart Disease: Yale-New Haven cardiologists
and diabetologists conduct clinical trial
Participants are needed for a clinical trial that will determine
the effectiveness of screening diabetic patients for silent
heart disease, that is blockages of coronary arteries that
may not be symptomatic but which may result in an eventual
heart attack.
Eligible participants include those with type 2 diabetes
who are free of any known heart disease and have no current
cardiac symptoms. All patients will undergo a comprehensive
evaluation, physical exam and EKG. Half of the participants
will also undergo cardiac perfusion imaging, a safe and effective
nuclear medicine study, much like a stress test, to detect
silent heart problems. Participants will then be contacted
by phone every six months for three years. There is no charge
for any of these services. [Trial closed. No longer recruiting
patients. Watch for results of the trial.]
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Manage your risk of heart disease
Although the link between diabetes and heart disease has been
more widely communicated in the last five years, this survey indicates
there is still a lack of understanding of the connection between
the two diseases.
Almost everyone with diabetes is very aware of some of the more
prominent complications of diabetes such as blindness, kidney
disease and peripheral vascular problems that may result in amputations.
These complications are generally restricted to patients with
diabetesunlike heart disease, which afflicts many Americans
without diabetes. This may be one reason this misconception continues
to exist in patients.
The fact is cardiovascular disease is the chief cause of death
in between 70 and 80 percent of patients with type 2 diabetes,
which is by far the more prevalent form of the disease. Diabetic
patients have high levels of blood sugar in their bodies, which
can damage vascular tissue and promote the atherosclerotic process.
And perhaps even more important than the blood sugar level itself
is a condition we call insulin resistance syndrome
or metabolic syndrome that is present in the vast
majority of patients with diabetes.
Metabolic syndrome
This condition is relatively common. Approximately 20 to 25 percent
of Americans have a cluster of characteristicsobesity, particularly
disproportionate amounts of abdominal fat; elevated blood pressure,
blood sugar and triglycerides and low levels of HDL, the good
cholesterol. Resistance to the action of the hormone insulin may
be the root cause of this syndrome.
The metabolic syndrome greatly increases the risk of diabetes,
heart attacks and stroke. This syndrome has led some scientists
to refer to the common soil hypothesis, that is both
diabetes and heart disease grow in the same soil of
metabolic syndrome; hence, the strong link between the two diseases.
Lifestyleincluding overeating
and a lack of exercisemay be the most important factor [in
causing metabolic syndrome].
The syndrome stimulates the diabetic process by taxing the pancreas
to make more and more insulin. Once this process takes hold, it
can be difficult to reverse, so preventive measures, including
low-fat diet, weight loss and exercise are very important. Though
experts say the syndrome may be caused by a combination of genes
and lifestyle factors, lifestyleincluding overeating and
a lack of exercisemay be the most important factor.
What is diabetes?
Diabetes is a disease in which your body is unable to properly
use and store glucose, a form of sugar. There are two major types
of diabetes:
- In type 1 (also called juvenile-onset
or insulin-dependent) diabetes, your body completely stops producing
insulin, a hormone that enables your body to use the glucose
in foods for energy. People with type 1 diabetes must take daily
insulin injections.
- In type 2 (also called adult-onset
or non insulin-dependent) diabetes, the body produces insulin,
but not enough to overcome an underlying resistance to its action.
Diabetes is defined as having a fasting blood sugar level of
126 mg/dl or greater on two separate occasions. If diabetes symptoms
exist and you have a random blood sugar taken at any time that
is equal to or greater than 200 mg/dl, and a second test shows
the same high blood sugar level, then you have diabetes.
Prediabetic state
In general, people who have a fasting blood sugar in the 110-125
mg/dl range are defined as having impaired fasting glucose,
which can be considered a prediabetic state. A similar condition
is referred to as impaired glucose tolerance. People
with such borderline blood sugar readings can reduce their risk
of type 2 diabetes by 58 percent by losing just 7 percent of their
body weight and by exercising moderately for 30 minutes per day.
What can you do to reduce your risk of heart disease?
If you've been diagnosed with diabetes, there are several things
you can do to reduce your risk of heart disease.
- Control your glucose levels. Follow
your doctor's advice about diet and exercise and be aware that
there are some new medications that, when used in combination
with other drugs, may help you get better control of your blood
sugar.
- Control your blood pressure and
ask your physician if you should be taking an ACE inhibitor.
New evidence indicates even patients with diabetes who do not
have high blood pressure may reduce their risk of heart disease
by taking ACE inhibitors.
- Seek aggressive treatment for high
cholesterol. New evidence indicates even patients with diabetes
who do not have high cholesterol may reduce their risk of heart
disease by taking certain lipid-lowering drugs, known as statins.
- Stop smoking.
- Maintain a healthy weight.
- Exercise regularly.
- Talk to your doctor about taking aspirin
every day.
The incidence of diabetes is approaching epidemic proportions.
Both obesity and inactivity are becoming more common at younger
ages, and for the first time, we are seeing type 2 diabetes in
children in addition to the more highly publicized worldwide increase
among people of all ages. Healthy eating habits and regular exercise
can help prevent diabetes, but if you are diagnosed, learn all
you can about how to minimize your risks for serious health consequences.

Dr. Inzucchi is an attending physician at Yale-New Haven Hospital,
as well as the director of the Yale Diabetes Center and associate
professor of medicine at the Yale University School of Medicine.
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