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Yale-New Haven Hospital, New Haven, Connecticut, USA HealthLINK: Women's Health

May 10, 2004

News this month
Exercise improves survival rate for heart failure patients

People with heart failure who are engaged in exercise programs experience improved survival rates according to a study published in the online version of the British Medical Journal.

Exercise seemed to achieve an increase in survival and a decrease in hospital admissions.

The study, conducted by Dr. Massimo Piepoli of Royal Brompton Hospital in London and his colleagues, analyzed data from nine separate clinical trials, involving over 800 heart failure patients who were involved in exercise programs for a minimum of eight weeks. The majority of studies used either a bicycle ergometer or a combination of different exercises, including jogging, swimming and walking.

Each clinical trial randomized patients with stable heart failure to either participate in an exercise program or to receive routine therapy without formal exercise training. Investigators found that the heart failure patients in the exercise group were less likely to die than those receiving routine therapy only. The exercise patients also experienced a significant decrease in hospital admissions. The benefits were seen without regard to the underlying cause of heart failure and extended equally to all age groups and among men and women.

Fewer deaths; delayed hospital admissions
Eighty-eight of the exercise patients died during the follow-up period. These deaths occurred after an average of 618 days. There were 105 deaths among the nonexercise control group, occurring after an average of 421 days. The exercise groups also stayed out of the hospital longer. Average times to hospital admission were 426 days for the exercise group versus 371 days in the control group.

Your exercise capacity predicts your chances of dying prematurely better than many other risk factors, including smoking, high blood pressure, blood cholesterol levels and diabetes.

Although how exercise specifically increases survival rates is unknown, according to the researchers, all observational studies confirm that improved exercise capacity decreases the risk of premature death among heart failure patients and healthy patients as well. Exercise capacity is the maximum amount of metabolic energy you’re forced to produce in a treadmill test. When people are pushed to the max on a treadmill test, it’s possible to measure their exercise capacity in units called METS — metabolic equivalents. The higher the METS, the better. Your exercise capacity predicts your chances of dying prematurely better than many other risk factors, including smoking, high blood pressure, blood cholesterol levels and diabetes. Even when the amount of time spent exercising as part of a program is relatively small, supervised exercise is likely to lead to a more active lifestyle.

Currently, exercise is not widely prescribed for people with chronic heart failure due to lack of evidence of its long-term effectiveness.




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Stuart. Katz, MD portrait.

Exercise benefits all, but compliance an issue

As we become more effective at treating heart attacks and other forms of heart disease, patients with heart disease are living longer, and as they age, they may be at increased risk of developing heart failure. Currently about five million Americans have some degree of heart failure, and this number is projected to rise significantly as the baby boomer population ages.

“Patients with heart disease are living longer, and as they age, they may be at increased risk of developing heart failure.”

Fortunately, over the last decade we’ve made major advances in treating the disease with medication. Until recently, exercise was not considered an option for these patients. Heart failure patients have damaged hearts that fail to pump blood adequately. Just as the severity of heart attacks varies, so does the severity of heart failure. People may experience relatively mild cases and feel discomfort only after vigorous exercise, or they may have trouble breathing and feel weak after walking across a room.

This study only reviewed trials that included patients who were able to enter exercise programs that entailed some level of aerobic effort. There are some severely ill patients who are not able to exercise enough to meet the study’s criteria, but most heart failure patients can exercise to some degree.

Customized programs safest approach
At the Yale Congestive Heart Failure program, we tailor our exercise recommendations to the specific needs and condition of each patient. Safety is a primary consideration. Patients with heart failure should always talk with their doctors about beginning a formal exercise program and seek their assistance on doing it safely.

There isn’t any one size fits all program. Some people with heart failure, including those with unusual heart rhythms, may need to be monitored during exercise. Others may be able to exercise safely at home after they have undergone a supervised training program. Stationary bicycles may be too strenuous for some. Swimming is usually not recommended since immersion in water can result in shifts in body fluids that can be detrimental for some patients.

“Exercise is beneficial not just for heart failure patients, but for all of us.”

We refer some patients to formal cardiac rehabilitation programs, but unless there’s underlying coronary artery disease, insurance programs may not cover exercise programs.

For many patients, a regular walking program is the safest solution. Walking at a comfortable pace three or four times a week can have a definite beneficial effect on how patients feel. Exercise is particularly important for heart failure patients since improved conditioning makes it possible for them to go about their normal daily routines more easily and helps them remain independent longer.

There’s no question that exercise is beneficial not just for heart failure patients, but for all of us. Exercise provides a host of physiological benefits, including improved blood vessel function and improved muscular function. Exercise may also improve the flow of oxygen to muscles and lower levels of hormones that can contribute to heart failure symptoms.

Motivation: a challenge for all
The challenge is motivation. Only about a half of our patients comply with our exercise recommendations. The national obesity epidemic is clearly related to a decrease in physical activity. Exercising just 40 to 50 minutes three or four times a week can help people shed up to 5 percent of their body weight without changing eating habits, but clearly, in spite of all of the positive press, most people aren’t exercising regularly.

Limitations of the study
The study in the BMJ does have some limitations. There were a relatively small number of patients (395) in the exercise group, fewer women (11.6%) and few patients who had other illnesses in addition to their heart failure. In addition, it may be that patients who comply with exercise programs tend to take better care of themselves overall. It’s difficult to draw any specific conclusions about outcomes from this research.

It’s clear we need larger, longer-term trials to clarify the role of exercise and how it affects outcomes in a wide variety of patients. The National Institutes of Health is currently conducting a large multicenter trial that hopefully will provide us with more definitive information. The Yale Congestive Heart Failure program is participating in this study.


Dr. Katz is the director of the Yale Congestive Heart Failure Program, a cardiologist at Yale-New Haven Heart Center and Yale-New Haven Hospital, and associate professor of internal medicine at Yale.


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